Genes VS. Lifestyle: What better Determines Cognitive Aging?

In a nutshell, this study utilized a survey to determine what people believe about the factors leading to cognitive aging - whether it’s determined by genetics or mostly influenced by lifestyle choices. They analyzed responses from 3,130 adults over 40 years old in the UK, and found that majority (62.2%) of people believe that both genes and lifestyle equally affect cognitive aging, while others (19.5%) think lifestyle matters more, and some (18.3%) perceive that genes have bigger impact.

This study also highlighted that those who believe genes play a larger role in cognitive decline were less likely to engage in brain-boosting activities, like reading, learning and experiencing new things, or doing puzzles. This suggests that if people think they cannot control cognitive aging, they have lower chances to take steps to improve or maintain their brain health.

Despite the research limitations indicated in this study, it is clear that public awareness about how lifestyle choices can positively influence brain health should be emphasized. But, is cognitive aging just mostly written in our DNAs? Or are people just underestimating the power of lifestyle in brain health?

Source: https://pubmed.ncbi.nlm.nih.gov/35310240/

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The problem with these studies is they never account for who has the time and resources to do all these brain-healthy activities. Working two jobs to survive? Can’t afford hobbies or classes? The “lifestyle choice” framing ignores massive systemic inequalities. It’s not always about belief, sometimes it’s about access.

Some of the most effective interventions are surprisingly accessible. Regular walking, for example. It costs nothing and has massive cognitive benefits. The study isn’t saying everyone needs workout subscriptions or cooking classes, it’s saying beliefs matter because they affect whether people even try the free stuff available to them.

This actually makes so much sense. It’s frustrating when people use genetics as an excuse to not even try. We should definitely be teaching people more about what they can actually do to keep their minds healthy as they age.

@psyche.shei The neuroscience evidence clearly shows brain plasticity persists throughout life, though it declines with age. Neurogenesis in the hippocampus continues into old age and is enhanced by exercise, learning, and environmental enrichment. Epigenetic modifications from lifestyle factors (diet, stress, exercise) affect gene expression related to neuronal health. So while your genetic baseline matters, the trajectory of cognitive aging is substantially modifiable. The Lancet Commission on dementia prevention identified 12 modifiable risk factors that account for approximately 40% of dementia cases - this wouldn’t be possible if genes determined everything.

@NiLe What are those 12 modifiable risk factors?

@M.Evanta They include: less education, hypertension, hearing impairment, smoking, obesity, depression, physical inactivity, diabetes, low social contact, excessive alcohol, traumatic brain injury, and air pollution. Many are lifestyle-related and preventable. Addressing these collectively could prevent or delay a substantial proportion of dementia cases.

@prettymarion960 You’re absolutely right that systemic barriers profoundly limit ‘lifestyle choices.’ The core value of this study, however, is the demonstrated link between a ‘fixed’ genetic belief and lower motivation to even attempt any brain-boosting activity. The takeaway isn’t to blame the individual; it’s for public health campaigns to stop sending messages that suggest cognitive decline is inevitable (‘it’s all in your genes’).

@feltonwhitsey We need to be teaching people not just what activities to do, but why they work, specifically against the myth of genetic inevitability. The study suggests a two-part educational message: 1) Lifestyle factors play a powerful role in brain health, and 2) Engaging in activities that involve ‘mental challenge/novelty’ is key. This targeted messaging is the antidote to the ‘genetics excuse’ you mentioned.

@NiLe What’s powerful about this list is the overlap between the preventative measures. Managing hypertension, obesity, and diabetes all involve similar positive changes (e.g., diet and exercise). The study found that people who believed in lifestyle were more likely to engage in positive behaviors. Therefore, a successful campaign that encourages a belief in cognitive malleability can lead to positive changes that collectively reduce the risk across multiple items on this essential list.